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LOsG did not alter expressions of pancreatic ER stress, inflammation, and hypoxia-responsive genes It has been suggested that endoplasmic reticulum (ER) stress, inflammation, and hypoxia are related to the underlying mechanism of -cell dedifferentiation 28

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It contributes to a compositional shift in gut microbiota characterized by a dramatic decrease in the diversity and abundance of several beneficial bacteria (reviewed in Dinan and Cryan, 2017)